Until 2026, the subject scope of the Collection of Scientific Works of Tbilisi Humanitarian University covered current issues in the socio-economic, financial, international relations, tourism, law, healthcare, and ecology fields.

From 2026 onward, the journal's scientific profile has been defined on the basis of five research directions (subject-area sections) officially approved by the University: dentistry, psychology, business administration, law, and the teaching of the Georgian language (linguistics and pedagogy).

Within these directions, the journal pays particular attention to current challenges of contemporary science, namely:

• Digital transformation and the application of artificial intelligence in the relevant fields;
• Issues of public health and psychosocial well-being;
• Sustainable and responsible development;
• Digital ethics and issues of its regulation;
• Interdisciplinary and cross-sectoral research that goes beyond the framework of a single field.

The detailed research priorities established for each subject-area section are periodically updated by the University.